Wojciech K. Kasprzak
( pr. Voytek Casp-shack )

Bioinformatics Analyst Programmer

Basic Science Program
Leidos Biomedical Research, Inc., ( Leidos )
Frederick National Laboratory for Cancer Research

Utilizing resources of the
Advanced Biomedical Computing Center: ABCC

In support of:
RNA Structure and Design Section
RNA Biology Laboratory (RNABL)
National Cancer Institute at Frederick
Building 469, Rm 226
Frederick, MD 21702

Phone: 301 846 5537
Fax: 301 846 6911

Professional Society memberships: Biophysical Society, The RNA Society

Reseach interests and ongoing projects:
  • Design and characterization of RNA-based nano-scale structures and other RNA 3D modeling - see the 2014 featured stories in CCR Connections and CCR In the Journals. Watch our a video on the subject of Designing RNA Nanoscaffolds to Deliver Drugs.

  • RNA-structure dynamics explored with full atom, explicit solvent Molecular Dynamics and coarse-grained methods, such as the Anisotropic Network Model, a form of Elastic Network Model.

  • RNA Junction Database - a databas of 3D RNA junctions extracted from PDB entries for the purpose of RNA nanostructure design. All the junctions have been subjected to energy minimization in Amber (reaching nearest local minimum), and their RMSD relative to the initial structure and the minimized 3D coordinates are also available.

  • Utilization of our Massively Parallel Genetic Algorithm MPGAfold to determine multiple functional structures (states) of RNA sequences, such as those we have shown for the HDV Type III (with differences for the strains from Ecuador and Peru), HIV 5'UTR, hok/sok and pstvd systems (see publications).

  • StructureLab - a heterogeneous computing environment workbench for multifaceted RNA secondary structure prediction and analysis. You can download binaries of this software package for PC/Linux and SGI/Irix platforms.

Here is a PubMed search of my publications (journal papers; a few missed), and here is my CV with full bibliography (papers & book chapters) and presentations (PDF). (as of July 2015)

Frederick, Maryland, USA:

Last revision: Nov. 07, 2016 by kasprzaw@mail.nih.gov